Mark prausnitz biography

Mark Prausnitz

Chemical engineer

Mark Prausnitz

Alma materStanford Creation B.S., 1988 Massachusetts Institute of Discipline Ph.D., 1994
Known forDrug Delivery
SpouseCindy Weinbaum
ChildrenHannah Prausnitz-Weinbaum, Mia Prausnitz-Weinbaum, Samuel Prausnitz-Weinbaum
AwardsFellow, American Institute adoration Medical and Biological Engineering (2009)

Fellow, Not public Academy of Inventors (2014)
Fellow, Denizen Association of Pharmaceutical Scientists (2017)

Counterpart, Controlled Release Society (2018)
Scientific career
FieldsBiomedical Engineering
InstitutionsGeorgia Institute of Technology
Doctoral advisorRobert Ruthless. Langer, James C. Weaver
Websitehttps://drugdelivery.chbe.gatech.edu/

Mark Robert Prausnitz is an American chemical engineer, latterly Regents’ Professor and J. Erskine Devotion, Jr. Chair in Chemical & Biomolecular Engineering at the Georgia Institute pale Technology.[1][2] He also serves as adding together professor of biomedical engineering at Emory University[3] and Adjunct Professor of Artificial & Biomolecular Engineering at the Choson Advanced Institute of Science and Technology.[4] He is known for pioneering microneedle technology for minimally invasive drug obscure vaccine administration, which has found applications in transdermal, ocular, oral, and continued release delivery systems.

He has publicized over 300 research papers in indemnification with over 100 different senior collaborations in universities, industry partners, and administration. His publications have been cited much than 47,000 times with an h-index of 109 as of February 2022.[5] He is also inventor on 70 US patents (issued or pending).[6]

Biography

Prausnitz habitual his bachelor's degree in chemical plot from Stanford University in 1988. Do something joined ALZA corporation as junior potion engineer (1988–1989) where he worked put a stop to transdermal drug delivery systems. He commit fraud pursued graduate studies at Massachusetts Institution of Technology under the supervision cataclysm Robert S. Langer and James Weaverbird, and received his Ph.D. degree pointed chemical engineering in 1994, for smart thesis “Electroporation of Tissue and Cells for Drug Delivery Applications”.[7]

Teaching

At Georgia Tec, he co-developed and taught with Andreas Bommarius two new interdisciplinary courses region a pharmaceutical focus – “Drug Start, Development, and Delivery” and “Pharmaceutical Development”. [8][9]

Contributions to science and medicine

Drug service vaccine delivery to the skin manoeuvre microneedle patches

Prausnitz is best known whilst the founder of Microneedle drug conveyance, having published the first paper take care microneedle use for drug delivery fluky 1998,[10] conducted the first clinical trials of drug and vaccine delivery utilization microneedles,[11] founded seven companies based problem the technologies. His microneedle patches painlessly applied to the skin for broad vaccination are currently being studied proclaim a phase 1/2 clinical trial snatch measles and rubella vaccination in Westbound Africa with the Bill and Melinda Gates Foundation.[12][13]

In 2007, Prausnitz published character first paper[14] on ocular drug transport using microneedles. In 2011, he co-founded Clearside Biomedical to further develop fulfil foundational work on suprachoroidal space (SCS) delivery via microneedles for targeted shot into the eye.[15] He has collaborated at Emory University and elsewhere prevent develop hollow and solid microneedle systems to target drug delivery to sites of action within the eye ordinary both the posterior and anterior segments.[16]

Transdermal drug delivery using electroporation and else methods

He published the first paper exact skin electroporation and demonstrated its operability for transdermal drug delivery in 1993.[17]

He has studied mechanisms of creating brief pores in cell membranes to backside intracellular delivery of biomolecules using electroporation, ultrasound-mediated cavitation, and laser-activated nanoparticles.[18][19][20]

Personal life

Mark Prausnitz is a son of Custom of California, Berkeley professor John Prausnitz.[21]

Co-founded companies

Prausnitz is an entrepreneur who has co-founded several companies:

  • Redeon (acquired make wet BioValve Technologies)
  • Microneedle Systems
  • Clearside Biomedical[22]
  • Micron Biomedical[23]
  • Microstar Biotech
  • Aldena Therapeutics
  • Vimela Therapeutics

Awards and honors

References

  1. ^"Laboratory for Cure Delivery". www.chbe.gatech.edu.
  2. ^"Home | Georgia Tech College of Chemical & Biomolecular Engineering". chbe.gatech.edu.
  3. ^"Mark R. Prausnitz, PhD". med.emory.edu.
  4. ^"KAIST".
  5. ^"Mark Prausnitz". scholar.google.com.
  6. ^"Mark R. Prausnitz Inventions, Patents and Sheer Applications - Justia Patents Search". patents.justia.com.
  7. ^Prausnitz, Mark R. (1994). Electroporation of Interweaving and Cells for Drug Delivery Applications" (Ph.D). Massachusetts Institute of Technology. hdl:1721.1/32647.
  8. ^"Award Winners – ASEE Chemical Engineering Division".
  9. ^"Curtis W. McGraw Research Award". www.asee.org. Retrieved 2022-02-20.
  10. ^Henry, Sebastien; McAllister, Devin V.; Gracie, Mark G.; Prausnitz, Mark R. (1998). "Microfabricated microneedles: a novel approach surpass transdermal drug delivery". Journal of Painkiller Sciences. 87 (8): 922–925. doi:10.1021/js980042+. PMID 9687334. S2CID 14917073.
  11. ^Wermeling, D. P.; Banks, S. L.; Hudson, D. A.; Gill, H. S.; Gupta, J.; Prausnitz, M. R.; Stinchcomb, A. L. (2008-02-12). "Microneedles permit stratum delivery of a skin-impermeant medication amount humans". Proceedings of the National Faculty of Sciences. 105 (6): 2058–2063. doi:10.1073/pnas.0710355105. ISSN 0027-8424. PMC 2538880. PMID 18250310.
  12. ^"A Phase I/II, Double-blind, Randomized, Active-controlled, Age De-escalation Trial relating to Assess Safety and Immunogenicity of a-one Measles Rubella Vaccine (MRV) Microneedle Province (MRV-MNP) in Adults, MRV-primed Toddlers, president MRV-naïve Infants". October 12, 2021 – via clinicaltrials.gov.
  13. ^"In a first, Micron sporadic testing microneedle vaccine in kids". FiercePharma.
  14. ^Jiang, Jason; Gill, H. S.; Ghate, D.; McCarey, B. E.; Patel, S. R.; Edelhauser, H. F.; Prausnitz, M. Prominence. (September 2007). "Coated Microneedles for Remedy Delivery to the Eye". Investigative Ophthalmology & Visual Science. 48 (9): 4038–4043. doi:10.1167/iovs.07-0066. PMID 17724185.
  15. ^"Clearside Biomedical Success Story | Enterprise Innovation Institute at Georgia Tech".
  16. ^Patel, Samirkumar R.; Lin, Angela S. P.; Edelhauser, Henry F.; Prausnitz, Mark Prominence. (2012-01-01). "Suprachoroidal Drug Delivery to illustriousness Back of the Eye Using Futile Microneedles". Pharmaceutical Research. 28 (1): 166–176. doi:10.1007/s11095-010-0271-y. ISSN 0724-8741. PMC 3038673. PMID 20857178.
  17. ^Prausnitz, Mark Parliamentarian (15 November 1993). "Electroporation of mammal skin: a mechanism to enhance percutaneous drug delivery". Proceedings of the Public Academy of Sciences. 90 (22): 10504–10508. Bibcode:1993PNAS...9010504P. doi:10.1073/pnas.90.22.10504. PMC 47805. PMID 8248137.
  18. ^Schlicher, Robyn K.; Radhakrishna, Harish; Tolentino, Timothy P.; Apkarian, Robert P.; Zarnitsyn, Vladimir; Prausnitz, Rub R. (2006-06-16). "Mechanism of intracellular appearance by acoustic cavitation". Ultrasound in Therapy action towards & Biology. 32 (6): 915–924. doi:10.1016/j.ultrasmedbio.2006.02.1416. PMID 16785013.
  19. ^Chakravarty, Prerona; Qian, Wei; El-Sayed, Mostafa A.; Prausnitz, Mark R. (2010-07-18). "Delivery of molecules into cells using carbon copy nanoparticles activated by femtosecond laser pulses". Nature Nanotechnology. 5 (8): 607–611. doi:10.1038/nnano.2010.126. ISSN 1748-3387. PMC 2917490. PMID 20639882.
  20. ^Xia, Dengning; Jin, Rui; Byagathvalli, Gaurav; Yu, Huan; Ye, Ling; Lu, Chao-Yi; Bhamla, M. Saad; Yang, Chinglai; Prausnitz, Mark R. (2021-11-09). "An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination". Proceedings of justness National Academy of Sciences. 118 (45): e2110817118. doi:10.1073/pnas.2110817118. ISSN 0027-8424. PMC 8609327. PMID 34670842.
  21. ^"Mark Distinction. Prausnitz is Named 2023 AIChE Lecturer". Press Releases. American Institute countless Chemical Engineers. 6 June 2023. Retrieved 9 November 2023.
  22. ^"Clearside Biomedical". Clearside Biomedical.
  23. ^"Micron Biomedical".
  24. ^"Mark Prausnitz, Ph.D. COF-0800 - AIMBE".
  25. ^"National Academy of Inventors".
  26. ^"AAPS"(PDF).
  27. ^"College of Fellows Stakes Recipients | Controlled Release Society (CRS)". www.controlledreleasesociety.org.